Table 2.
Comparison of therapeutic failure rates for study groups, using the ITT approach and analysis of perprotocol after 20 and 45 days of treatment*
| Children | Adult | OR (95% CI) | χ2 | P value | ||
|---|---|---|---|---|---|---|
| Treatment | Perprotocol | 40/51 (78.4%) | 20/49 (40.8%) | 0.190 (0.079–0.456) | 14.733 | 0.0001 |
| After 20 days | ITT | 45/56 (80.4%) | 27/56 (48.2%) | 0.228 (0.098–0.528) | 12.600 | 0.0003 |
| Treatment | Perprotocol | 33/51 (64.7%) | 18/49 (36.7%) | 0.317 (0.140–0.717) | 7.824 | 0.0051 |
| After 45 days | ITT | 38/56 (67.9%) | 25/56 (44.6%) | 0.382 (0.177–0.825) | 6.132 | 0.0132 |
*
ITT = intention-to-treat; OR = odds ratio; CI = confidence interval; Perprotocol = analysis excluded patients who were lost to follow-up. Analysis for ITT included patients lost to follow-up throughout the study who were considered to have experienced treatment failure.