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Guinea pigs were aerosol-infected with virulent Mycobacterium tuberculosis. All animals developed multiple pulmonary nodules (A). Histopathological evaluation of these lesions revealed necrotizing granulomatous inflammation (B) (hematoxylin-eosin, original magnification ×40). The inset shows acid-fast bacilli (Ziehl-Neelsen, original magnification ×1000).
