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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: Cell. 2011 Jan 7;144(1):79–91. doi: 10.1016/j.cell.2010.12.016

Figure 7.

Figure 7

Model for the cell non-autonomous nature of the UPRmt.

Cells experiencing mitochondrial stress, in this scenario neuronal cells (circles) marked within the yellow box, produce a signal that is transmitted from the mitochondria to the nucleus to regulate the expression of genes regulated by UBL-5 and possibly DVE-1. These cells serve as sending cells and produce an extracellular signal (mitokine) that can be transmitted to distal, receiving cells, in this case intestinal cells marked in the green box. Receiving cells perceive the mitokine and induce the mitochondrial stress response. See also Figure S5.