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. 2011 Mar 22;6(3):e18059. doi: 10.1371/journal.pone.0018059

Figure 7. SLC39A14 positively regulates gluconeogenesis via GCGR signaling in the liver.

Figure 7

(A) Hepatic Pepck and Gcgr levels in 18-hours fed or fasted control (Ctrl) and Slc39a14-KO mice (16-week-old, n = 2). Data represent the mean ± S.D. (***P<0.001). (B) Plasma glucose level in 18–36-hours fasted control (Ctrl) and Slc39a14-KO mice (7–52-week-old, n = 8). Data represent the mean ± S.E.M. (*P<0.05). (C) cAMP level and PDE activity in the liver from control (Ctrl) and Slc39a14-KO mice (4–8-week-old, n = 3). Data represent the mean ± S.D. (*P<0.05, **P<0.01). (D) Hepatic Zn and Fe levels in control (Ctrl) and Slc39a14-KO mice measured by ICP-MS. Data represent the mean ± S.D. (*P<0.05). (E) Hepatic Mt-I level in control (Ctrl) and Slc39a14-KO mice (16-week-old, n = 2). Data represent the mean ± S.D. (**P<0.01).