Table 4.

Univariate survival analysis of patients with primary ovarian cancer. (A) All 70 ovarian cancer patients. (B) Patients stratified by histology.

A
		Progression-free survival		Overall survival
Variable		No. Patients (relapsed/total)	P	No. Patients (died/total)	P
Age	≤60 yrs.	17/29	0.33	14/29	0.002
	>60 yrs.	23/41		32/41
FIGO stage	I/II	2/16	0.001	6/16	0.012
	III/IV	38/54		40/54
Tumor grade	I/II	22/49	0.01	28/49	0.032
	III	18/21		18/21
Residual disease	no	8/27	<0.001	10/27	<0.001
after surgery	yes	32/43		36/43
Histology	serous	24/33	0.02	25/33	0.215
	mucinous	11/30		18/30
	endometroid	5/7		3/7
Chemotherapy	no	1/8	0.09	4/8	0.544
	yes	39/62		42/62
Nuclear area	small (≤median)	16/35	0.02	19/35	0.015
	large (>median)	24/35		27/35
Hyperploidy	low (≤median)	19/35	0.43	20/35	0.069
	high (>median)	21/35		26/35
Aneuploidy	low (≤median)	17/35	0.07	19/35	0.031
	high (>median)	23/35		27/35
Proliferation index	low (≤median)	18/35	0.32	21/35	0.220
	high (>median)	22/35		25/35
Chr1 Sat2 hypomethylation	≤score 2	18/35	0.02	29/49	0.017
	>score 2	22/35		17/21
Chr1 Sat α hypomethylation	≤score 2	20/44	0.048	27/44	0.460
	>score 2	19/24		18/24
LINE1 DNA-hypomethylation	low (≤median)	13/35	0.001	18/35	0.006
	high (>median)	27/35		28/35

B
		Serous ovarian cancer		Mucinous ovarian cancer
Variable		Progression-free survival	Overall survival	Progression-free suvival	Overall survival
		P	P	P	P
Nuclear area	small (≤median) large (>median)	0.465	0.304	0.006	0.003
Hyperploidy	low (≤median) high (>median)	0.899	0.647	0.010	< 0.001
Aneuploidy	low (≤median) high (>median)	0.101	0.303	0.020	0.019
Proliferation	low (≤median) high (>median)	0.594	0.641	0.010	0.056
Chr1 Sat2 hypomethylation	≤score 2 >score 2	0.344	0.087	0.045	0.018
Chr1 Sat α hypomethylation	≤score 2 >score 2	0.717	0.941	0.18	0.42
LINE1 DNA-hypomethylation	low (≤median) high (>median)	0.278	0.313	< 0.001	0.004

Note: The significance level (P) was determined by log-rank test.