Table 1.
Cardiometabolic and reproductive profiles of both groups before and after treatment.
| Atorvastatin (n=9) |
Placebo (n=11) |
Atorvastatin vs. Placebo |
|||||
|---|---|---|---|---|---|---|---|
| Before Mean (SD) | After Mean (SD) | Within-group Mean Difference(95% CI) [p-value] |
Before Mean(SD) | After Mean(SD) | Within-group Mean Difference(95% CI) [p-value] |
Between-group Mean Difference(95% CI) [p-value] |
|
| Cardiometabolic profile | |||||||
| Age (years) | 33.8 (4.3) | - | - | 29.4 (5.8) | - | - | - |
| BMI (kg/m2) | 40.1 (11.8) | 38.2 (8.4) | 0.2 (−0.4,0.9) [0.43] |
36.0 (10.4) | 35.8 (10.8) | 0.05 (−0.47,0.56) [0.85] |
0.2 (−0.6,1.0) [0.63] |
| Systolic BP(mm Hg) | 119.8 (15.8) | 112.0 (13.2) | −8.5 (−16.6,−0.4) [0.04] |
114.5 (14.4) | 111.4 (8.8) | −2.5 (−9.9,4.8) [0.47] |
−5.9 (−16.9,5.0) [0.27] |
| Diastolic BP(mm Hg) | 70.8 (14.8) | 64.3 (12.3) | −6.7 (−12.7,−0.8) [0.03] |
64.6 (8.0) | 65.4 (8.1) | 1.1 (−4.2,6.4) [0.67] |
−7.8 (−15.8,0.1) [0.05] |
| Total Cholesterol(mg/dl) | 215.8 (39.0) | 132.0 (19.7) | −82.5 (−100.7,−64.4) [<.001] |
202.8 (28.3) | 192.1 (33.6) | −11.7 (−28.0,4.6) [0.15] |
−70.8 (−95.2,−46.4) [<.001] |
| HDL-Cholesterol(mg/dl) | 44.4 (14.6) | 47.8 (11.8) | 3.2 (−1.4,7.7) [0.16] |
46.5 (8.6) | 46.8 (8.4) | −0.2 (−4.3,3.9) [0.92] |
3.4 (−2.7,9.5) [0.26] |
| LDL-Cholesterol(mg/dl) | 140.7(24.6) | 68.5 (19.3) | −70.2 (−86.3,−54.0) [<.001] |
131.3(21.6) | 118.8(26.8) | −12.6 (−27.1,1.9) [0.08] |
−57.6 (−79.3,−35.9) [<.001] |
| Triglycerides(mg/dl) | 153.3(84.9) | 78.5 (24.8) | −77.1 (−109.8,−44.5) [<.001] |
125.5(54.2) | 132.5(45.7) | 5.0 (−24.5,34.5) [0.72] |
−82.2 (−126.2,−38.1) [<.001] |
| hsCRP (mg/L) | 8.0 (9.6) | 4.3 (5.4) | −3.6 (−6.5,−0.6) [0.02] |
7.2 (7.7) | 6.0 (7.3) | −1.1 (−3.8,1.5) [0.39] |
−2.4 (−6.4,1.5) [0.21] |
| Fasting Glucose(mg/dl) | 87.7 (9.0) | 87.8 (8.5) | 0.2 (−6.5,7.0) [0.94] |
85.3 (8.0) | 88.9(10.7) | 3.6 (−2.5,9.6) [0.23] |
−3.3 (−12.4,5.8) [0.45] |
| Fasting Insulin(μU/ml) | 18.6 (10.1) | 21.0 (11.8) | 1.4 (−2.6,5.4) [0.47] |
16.8 (9.5) | 15.9 (6.7) | −1.1 (−4.7,2.4) [0.51] |
2.5 (−2.8,7.9) [0.33] |
| AUC Glucose | 15693(2162) | 16136(2569) | 709 (−1044,2462) [0.40] |
15309(3692) | 15448(3165) | 123 (−1513,1758) [0.88] |
586 (−1811,2983) [0.61] |
| AUC Insulin | 12738(10010) | 17479(11929) | 3074 (387,5762) [0.03] |
9338(5208) | 9132(4466) | −311 (−2812,2191) [0.79] |
3385 (−287,7056) [0.07] |
| Peak BAC(ml/sec/mmHg) | 5.4 (2.9) | 6.9 (2.8) | 1.2 (0.0,2.4) [0.05] |
3.6(3.0) | 4.3(3.3) | 0.5 (−0.5,1.6) [0.30] |
0.7 (−0.9,2.3) [0.39] |
| FMD (%) | 12.0 (7.3) | 10.4 (4.6) | −1.5 (−7.0,3.9) [0.56] |
9.8 (5.8) | 10.2(2.9) | 0.4 (−4.5,5.3) [0.85] |
−2.0 (−9.3,5.3) [0.58] |
| Reproductive profile | |||||||
| Ferriman-Gallwey hirsutism score | 14.4 (6.2) | - | - | 15.7 (6.5) | - | - | - |
| Free T (ng/dl) | 18.1 (4.9) | - | - | 20.2 (8.7) | - | - | - |
| Total T (ng/dl) | 61.3 (16.9) | 47.1 (21.4) | −14.9 (−34.2,4.4) [0.12] |
92.3(49.8) | 75.7(43.6) | −16.7 (−34.0,0.6) [0.06] |
1.8 (−24.1,27.8) [0.88] |
| Androstenedione(ng/ml) | 3.4 (0.8) | 2.5 (0.9) | −0.9 (−1.3,−0.5) [<.001] |
3.8 (1.2) | 4.1 (1.2) | 0.2 (−0.2,0.5) [0.36] |
−1.1 (−1.6,−0.5) [<.001] |
| DHEAS (ng/ml) | 1630.0(873.1) | 1326.4(854.3) | −296.5 (−513.5,−79.5) [0.01] |
1701.5(681.3) | 1739.5(781.8) | 67.8 (−126.2,261.7) [0.47] |
−364.3 (−655.3,−73.2) [0.02] |
| Mean Ovarian Volume (mm3) | 15.1 (8.8) | 19.2 (7.0) | 0.9 (−7.2,9.1) [0.81] |
25.4(13.7) | 25.2 (9.9) | −2.5 (−8.8,3.7) [0.39] |
3.5 (−6.8,13.7) [0.48] |
Note: Data are presented as mean (SD).
AUC, area under the curve; BAC, brachial artery conductance; BMI, body mass index; BP, blood pressure; hsCRP, high sensitive C-reactive protein; FMD, flow-mediated dilation.