Table 3.
Association between clinical factors and psychiatric and neurodevelopmental disorders in the portion of the cohort with uncomplicated epilepsy.
| N | Any Psychiatric Diagnosis |
Internalizing Disorders |
Externalizing Disorders |
Neurodevelopmental Spectrum Disorders |
||
|---|---|---|---|---|---|---|
| Sex | ||||||
| Female | 171 | 41(24.0) | 31(18.1) | 19(11.1) | 36(21.1) | |
| Male | 171 | 50(29.2) | 22(12.9) | 43(25.2) | 43(25.2) | |
| p-value | 0.27 | 0.18 | 0.0008 | 0.37 | ||
| Onset Age | ||||||
| <2 Years | 52 | 6(11.5) | 1(1.9) | 6(11.5) | 11(21.2) | |
| 2–5 Years | 84 | 20(23.8) | 7(8.3) | 16(19.1) | 21(25.0) | |
| 5–10 Years | 145 | 43(29.7) | 29(20.0) | 25(17.2) | 34(23.5) | |
| 10+ Years | 61 | 22(36.1) | 16(26.2) | 15(24.6) | 13(21.3) | |
| p-value* | 0.002 | <0.0001 | 0.14 | 0.94 | ||
| Interview Age | ||||||
| <10 Years | 28 | 1(3.6) | 1(3.6) | 1(3.6) | 5(17.9) | |
| 10–15 Years | 123 | 24(19.5) | 8(6.5) | 21(17.1) | 28(22.8) | |
| 15–20 Years | 134 | 43(32.1) | 26(19.4) | 27(20.2) | 32(23.9) | |
| 20+ Years | 57 | 23(40.4) | 18(31.6) | 13(22.8) | 14(24.6) | |
| p-value* | <0.0001 | <.0001 | 0.05 | 0.53 | ||
| Syndrome | ||||||
| BECTS+ | 57 | 17(29.8) | 12(21.1) | 11(19.3) | 8(14.0) | |
| CAE | 51 | 12(23.5) | 4(7.8) | 10(19.6) | 13(25.5) | |
| JAE/ JME | 27 | 10(37.0) | 7(25.9) | 6(22.2) | 7(25.9) | |
| Other | 207 | 52(25.1) | 30(14.5) | 35(16.9) | 51(24.6) | |
| p-value* | 0.51 | 0.11 | 0.89 | 0.36 | ||
| Failed at least two drugs | ||||||
| No | 302 | 78(25.8) | 43(14.2) | 54(17.9) | 68(22.5) | |
| Yes | 40 | 13(32.5) | 10(25.0) | 8(20.0) | 11(27.5) | |
| p-value | 0.37 | 0.08 | 0.74 | 0.48 | ||
| 5+ years seizure-free at time of interview | ||||||
| No | 93 | 32(34.4) | 22(23.7) | 22(20.6) | 37(34.6) | |
| Yes | 249 | 59(23.7) | 31(12.5) | 40(17.0) | 42(17.9) | |
| p-value | 0.05 | 0.001 | 0.43 | 0.0007 | ||
| Ever seizure-free >5 years | ||||||
| No | 93 | 32(34.4) | 22(23.7) | 20(21.3) | 30(31.9) | |
| Yes | 249 | 59(23.7) | 31(12.5) | 42(16.9) | 49(19.8) | |
| p-value | 0.05 | 0.001 | 0.35 | 0.02 | ||
+
BECTS, Benign Epilepsy with Centro-Temporal Spikes; CAE, Childhood Absence Epilepsy, JAE, Juvenile Onset Epilepsy; JME, Juvenile Myoclonic Epilepsy
*
P-value for trend