Table 1.
Examples of cell-mediated drug delivery systems
| Type of cell-carrier | Therapeutic agent | Rote of administration1 | References |
|---|---|---|---|
| Alziemer's disease | |||
| Neural stem cells (NSCs) | ciliary neurotrophic factor (NTFs) | i.c. | 73 |
| NSCs | nerve growth factor (NGF) | i.c. | 65 |
| NSCs | brain-derived neurotropic factor (BDNF) | i.c. | 64, 75 |
| NSCs | choline acetyltransferase (ChAT) | i.c. | 72, 74 |
| Parkinson's disease | |||
| Monocytes, macrophages | catalase | i.v. | 29, 48, 71 |
| Fetal dopamine neurons | dopamine | i.c. | 76 |
| NSCs | glial cell-line derived neurotropic factor (GDNF) | i.c. | 77, 80 |
| NSCs | vascular endothelial growth factor (VGEF) | i.c. | 78, 79 |
| HIV-1 infection and neuroAIDS | |||
| Monocytes, macrophages | atazanavir, ritonavir, indinavir | i.v. | 14, 81-83 |
| Cancer | |||
| T-cells | doxorubicin | In vitro | 94 |
| Mesenchymal stem cells (MSCs) | tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) | ipsilateral | 93 |
| MSCs | interferon-β | i.v. | 86, 90, 95 |
| MSCs | oncolytic adenovirus | i.v. | 91, 92 |
| MSCs | antineoplastic agent | In vitro, in 3D collagen gels | 46 |
| Erythrocytes | 5-fluorouracil | i.v. | 96 |
| Monocytes and macrophages | Au-containing nanoparticles | In vitro, in spheroids | 85, 89 |
| Introperitoneal macrophages | 5-fluorouracil | i.p. | 50 |
| Bacterially-derived mini-cells | small interfering RNA (siRNA), cytotoxic drugs | i.v., i.t. | 97, 98 |
| Bacterially-derived mini-cells | doxorubicin | i.v., i.t. | 98 |
| Macrophages | imaging agents, quantum dots | i.v. | 103 |
| Macrophages | N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-gadolinium (Gd) chelates | i.v. | 104 |
| Hybridoma cell lines 2A and OX86 | anti-CD137 and anti-OX40 mAb | s.c. | 102 |
| Inflammation | |||
| Macrophages | betamethasone phosphate | in situ | 25 |
| Erythrocytes | glycoprotein A | 25 | |
| Sertoli cells | anti-inflammatory agent, curcumin | i.v. | 105 |
| Microbial Infections | |||
| Erythrocytes | antifungal agent, amphotericin B | in viro | 106 |
| Macrophages | chloroquine | i.v. | 107 |
| Epilepsy | |||
| Human MSCs and human embryonic stem cells | adenosine | i.c. in cell-encapsulation device | 108, 109 |
1
i.c., intracranial; i.v., intravenous; i.p., intraperitoneal; i.t., intratumoral; s.c., subcutaneous injections.