Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Mar 15;435(Pt 1):113–125. doi: 10.1042/BJ20101734

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

(A) A 30 s application of 10 mM ATP elicited a large increase in cytosolic calcium in B-K562 cells that slowly returned to baseline levels as ATP was washed out. (B) A comparable ATP application in V-K562 cells did not affect baseline calcium levels. Application of 10 mM CPA, a reversible SERCA pump inhibitor, illustrates that it was possible to evoke a measurable change in cytosolic calcium in these cells. (C) Analysis of ATP responsiveness in B-K562 and V-K562 cells on days 4 and 7 after PMA-induced differentiation in culture found that B-K562 cells were significantly more responsive to ATP than the V-K562 cells on both days 4 (B-K562, n=54; V-K562, n=16) and 7 (B-K562, n=20; V-K562, n=39). **P<0.005.