Table 3.
Adjusted Hazard Ratio for the Risk of Any CHD Event in Adulthood in Relation to a 1-Unit Increase in BMI z Score in Models Unadjusted and Adjusted for Birth Weight in a Cohort of 208,433 Children.*
Age | Boys | Girls | ||
---|---|---|---|---|
Model Unadjusted for Birth Weight | Model Adjusted for Birth Weight | Model Unadjusted for Birth Weight | Model Adjusted for Birth Weight | |
relative risk (95% confidence interval)† | ||||
7 yr | 1.09 (1.05−1.12) | 1.10 (1.07−1.14) | 1.04 (1.00−1.09) | 1.05 (1.00−1.10) |
8 yr | 1.11 (1.08−1.15) | 1.13 (1.10−1.17) | 1.05 (1.00−1.10) | 1.06 (1.01−1.11) |
9 yr | 1.13 (1.10−1.17) | 1.15 (1.12−1.19) | 1.06 (1.01−1.11) | 1.07 (1.02−1.12) |
10 yr | 1.15 (1.11−1.18) | 1.16 (1.13−1.20) | 1.09 (1.04−1.15) | 1.10 (1.05−1.15) |
11 yr | 1.17 (1.14−1.20) | 1.19 (1.15−1.22) | 1.11 (1.06−1.17) | 1.12 (1.07−1.17) |
12 yr | 1.20 (1.16−1.23) | 1.21 (1.18−1.25) | 1.13 (1.08−1.19) | 1.14 (1.09−1.19) |
13 yr | 1.20 (1.17−1.24) | 1.22 (1.19−1.26) | 1.15 (1.10−1.20) | 1.15 (1.10−1.21) |
Analyses were stratified according to birth cohort. Birth weight is modeled as a cubic spline with five knots. Birth weight was recorded from 1943 and was available for 208,433 of the boys and girls.
Trend tests led to the rejection of the alternative of nonlinearity modeled as a restricted cubic spline with five knots (all P values >0.15).