Table 1.
CPGs Implicated in Cortical Plasticity
Gene | Adult Expression |
Developmental Expression |
Protein | ||
---|---|---|---|---|---|
Seizure Induced | Visually Induced | During CP for OD Plasticity | Activity-Dependent | ||
zif268 | + | + | + | + | Transcription factor |
c-fos | + | ND | + | + | Transcription factor |
jun B | + | ND | + | + | Transcription factor |
BDNF | + | + | + | + | Neurotrophin |
GAP-43 | + | + | + | + | Axon-specific growth-associated protein |
CaMKII | − | + | + | + | Ca2+ calmodulin–dependent kinase |
GAD | + | + | + | + | GABA synthetic enzyme |
COX-2 | + | + | + | + | Rate-limiting prostaglandin synthetic enzyme |
Egr3 | + | + | + | − | Transcription factor |
Arc | + | + | + | + | Dendrite-specific cytoskeletal-associated protein |
Narp | + | + | + | + | Ca2+-dependent lectin that promotes neuronal migration and dendrite growth |
cpg2 | + | + | + | ND | Structural protein |
cpg22 (homer) | + | + | + | + | EVH domain protein that binds to mGLuR c-terminus |
rheb | + | + | + | − | Small G protein |
cpg15 | + | + | + | + | Membrane-bound extracellular signaling molecule that promotes dendritic growth |
cpg29 | + | + | + | ND | ? |
MHC | + | ND | + | + | Major histocompatability protein |