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In vitro activity of triazole-cycloproparadicicol. (Preliminary biological evaluations were performed by Dr. Gabriela Chiosis and coworkers at MSKCC.)
 |
 |
 |
|---|---|---|
| compound | Hsp90 inhibition (IC50) | Inhibition of Kasumi-1 leukemia cell line (IC50) |
| cycloproparadicicol (4) | 160 nM | -- |
| triazole-cycloproparadicicol (5) | 400 nM | 650 nM |
| 17-AAG (3) | 600 nM | 620 nM |
