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. 2011 Feb 4;24(3):357–370. doi: 10.1021/tx100323m

Figure 9.

Figure 9

Inhibition of phagocytosis by THP-1 macrophages following pretreatment with lipid electrophiles. Fluorescent microscopy images (GFP Filter) of THP-1 macrophage phagocytosis following 30 min of pretreatment with the DMSO vehicle, 10 μM HNE, or 0.5 μM ONE and washout with PBS. Phagocytosis of fluorescent polystyrene latex beads after 3 h (A). Quantification of fluorescent bead uptake by THP-1 macrophages following pretreatment with electrophiles, washout, and exposure to fluorescent beads for 3 or 6 h (B). * p-value <0.05; **p-value <0.01 as compared to the 3 h and 6 h vehicle (DMSO) control, respectively.