Table 3.

Significant Effects of Trajectories on Drinking Outcomes

		Descriptive statistics by drinking trajectory

Outcome, mean(SD)	Significant effect	T1: Frequent (N=196)	T2: Very frequent (N=259)	T3: Nearly daily (N=219)	T4: Daily (N=354)	T5: Daily stopping early (N=198)
Percent days abstinent⁺⁺⁺	Main effect of trajectory⁺⁺⁺	87.4(16.6)	80.8(22.3)^*	70.3(28.9)^***	64.4(34.0)^**	84.8(22.9)

Percent heavy drinking days⁺⁺⁺	Main effect of trajectory⁺⁺⁺	9.6(13.9)	13.2(19.1)	17.9(23.9)^***	19.6(27.6)^**	10.4(19.4)

Good clinical outcome, n(%)⁺⁺	Main effect of trajectory⁺⁺	129 (80.1%)	149 (71.6%)	115 (65.7%)^**	190 (64.6%)^**	126 (75.5%)

	Interaction between trajectory and acamprosate⁺	Active acamprosate	Active acamprosate	Active acamprosate	Active acamprosate	Active acamprosate
		67 (83.8%)	75 (68.8%)^*	61 (71.8%)^*	99 (67.8%)^**	58 (69.9%)^*

		Placebo acamprosate	Placebo acamprosate	Placebo acamprosate	Placebo acamprosate	Placebo acamprosate
		62 (76.5%)	74 (74.8%)	54 (60.0%)^*	91 (61.5%)	68 (81.0%)

Abstinence from heavy drinking in last two months	Main effect of trajectory⁺	81 (45.0%)	101 (41.1%)	83 (40.5%)	138 (41.4%)	104 (55.9%)^*

	Interaction between trajectory and acamprosate⁺	Acamprosate	Acamprosate	Acamprosate	Acamprosate	Acamprosate
		41 (46.6%)	60 (47.6%)	46 (45.5%)	72 (43.9%)	44 (48.4%)

		Placebo	Placebo	Placebo	Placebo	Placebo
		40 (43.5%)	41 (34.2%)	37 (35.6%)	66 (39.1%)	60 (63.2%)^**

Continuous abstinence, n(%)	Main effect of trajectory⁺⁺⁺	36 (20.0%)	56 (22.8%)	30 (14.7%)	59 (17.9%)	65 (35.0%)^**

	Interaction between trajectory and naltrexone⁺	Naltrexone	Naltrexone	Naltrexone	Naltrexone	Naltrexone
		15 (17.1%)	36 (27.9%)	13 (11.7%)	33 (22.3%)	35 (36.5%)^**

		Placebo	Placebo	Placebo	Placebo	Placebo
		21 (22.8%)	20 (17.1%)	17 (18.3%)	26 (14.3%)	30 (33.3%)

NOTE: Significant overall test of differences among the five trajectories is denoted by the following superscripts next to the variable name:

⁺

<.05;

⁺⁺

<.01;

⁺⁺⁺

<.001. Significant comparisons to T1 are denoted by superscript s next to the number for the corresponding trajectory:

<.05;

^**

<.01;

^***

<.001.

All other interactions involving baseline trajectories were not significant.