Figure 2. Fine mapping of loci within the 8q24 region by tumor histologic type.
−Log10(p) values for 89 SNPs across the 8q24 region stratified by glioma morphologic subtype. Combined Mayo Clinic and UCSF data are shown. Mayo Clinic glioma cases (N=582) and controls (N=532), and UCSF oligodendroglioma (oligo) and mixed oligoastrocytoma (MOA) cases (N=191) and controls (N=192) were genotyped using the Illumina VeraCode platform. UCSF astrocytic glioma cases (N=673) and controls (602) were evaluated by the Illumina 370duo platform. For these latter gliomas, only 28 SNPs are illustrated. Arrows indicate the SNPs reported by Shete et al[3]. The recombination rate (in cM/mbase) across the region from HapMap release 27 (http://hapmap.ncbi.nlm.nih.gov/) is also shown.