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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Hum Pathol. 2011 Jan 15;42(5):688–701. doi: 10.1016/j.humpath.2010.08.021

Table 1.

Normal, adenoma, high grade dysplasia and cancer: Mean MMP activity/mg protein expressed in 3 types of units for patient-matched tissues from 30 individuals (no FAP cases)

Tissue Active MMP-2 Activity Pro-MMP-2 Activity Pro-MMP9 Activity
SDU TPH μU TLU SDU SPSμU TLU SDU SPSμiU TLU
Normal (n=30) 14.2 532.5 19.2×103 147.6 0.554 704.1×103 190.8 24.2 1640.9×103
Ad w/o HGD (n=18) 31.8 1,192.5 43.0 ×103 172.0 0.645 820.4×103 337.3 42.8 2900.8×103
Ad with HGD (n=16) 63.3 2,373.8 85.7 ×x103 178.5 0.669 851.5×103 581.3 73.8 4999.2×103
Cancer (n=12) 127.0 4,762.5 171.8 ×103 264.3 0.991 1260.7x103 726.7 87.2 6249.6×103

*SDU, serial dilution units (defined by serial dilution of sample required to detect minimal complete visible band); TPH (μU, thiopeptolide hydrolysis activity in microunits; SPS μU, synthetic peptide hydrolysis activity in microunits against the dinitrophenyl-linked synthetic peptide substrate 2,4-DNP-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH; TLU, Total Lab units, computer imaging units in band area × pixel intensity as defined by Nonlinear Dynamics Total Lab software.