Table 2.

Parameter estimates (robust standard errors) and approximate p-values from two fitted multinomial logit models that discriminate among colorectal tissue types using active MMP-2, pro-MMP-2 and pro-MMP-9 activity levels

	Fitted Multinomial Logit Model
	M1: Main effect of Active MMP-2	M2: Main effect of Active MMP-2, controlling for the main effects of Pro-MMP-9 & Pro-MMP-2
Adenoma (A) vs. Normal (N):
Intercept	−1.315*** (0.329)	−1.149** (0.504)
Active MMP-2	0.037** (0.012)	0.050** (0.017)
Pro-MMP-2		−0.005 (0.003)
Pro-MMP-9		0.001 (0.001)
High Grade Dysplasia(HGD) vs. Normal (N):
Intercept	−2.798*** (0.628)	−2.046** (0.716)
Active MMP-2	0.066*** (0.017)	0.095*** (0.030)
Pro-MMP-2		−0.013 (0.008)
Pro-MMP-9		0.001 (0.001)
Cancer (C) vs. Normal (N):
Intercept	−4.494*** (1.196)	−3.606** (1.316)
Active MMP-2	0.084*** (0.021)	0.114*** (0.033)
Pro-MMP-2		−0.014 (0.008)
Pro-MMP-9		0.001 (0.001)
−2LL	154.18	144.70
Pseudo-R2 Statistic	0.269	0.314

^*p<.05;

^**p<.01;

^***p<.001;

tissue samples, n=79, patients, n=30