Networks derived from Ingenuity software analysis of differential gene expression, comparing neutrophils from children with juvenile idiopathic arthritis in remission who were not taking medication with those from healthy controls. Genes showing higher expression in patients are shown in red, and those expressed at higher levels in controls are shown in green. A, Note the presence of genes normally associated with the regulation of adaptive immunity (e.g., CD3, CD2) in this network. B, Note that this network demonstrates overlapping groups of interleukin-4– and interferon-γ–regulated genes that we have previously described (23).