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. Author manuscript; available in PMC: 2011 Mar 23.
Published in final edited form as: Arthritis Rheum. 2009 May;60(5):1488–1495. doi: 10.1002/art.24450

Figure 3.

Figure 3

Networks derived from Ingenuity software analysis of genes differentially expressed in neutrophils from children with polyarticular juvenile idiopathic arthritis (JIA) who have achieved remission and are not taking medication and in neutrophils from healthy control children. Genes overexpressed in children with JIA are shown in red, and those expressed at higher levels in controls are shown in green. A, Shown is a network comprising of groups of proinflammatory genes (e.g., CCR5, interleukin-6 signal transducer [IL6ST]) regulated through the JUN and MYC transcription regulators. B, Shown is a network in which retinoic acid, a known modulator and attenuator of inflammation, is a prominent system “hub.”