Table 1.
Characteristics | Responders (n = 252), n (%) | Non-responders (n = 349), n (%) | P-valuea |
---|---|---|---|
Age group, years | <0.001 | ||
18–34 | 69 (27) | 176 (50) | |
35–54 | 140 (56) | 143 (41) | |
55–74 | 43 (17) | 30 (9) | |
Sex | 0.001 | ||
Female | 192 (76) | 216 (62) | |
Male | 60 (24) | 133 (38) | |
Ethnicity | 0.046 | ||
White | 246 (98) | 329 (94) | |
Otherb | 6 (2) | 20 (6) | |
Trial centre | 0.039c | ||
Bristol | 229 (91) | 292 (84) | |
Birmingham | 21 (8) | 51 (15) | |
Newcastle | 2 (1) | 6 (2) | |
Employment status | 0.009 | ||
Employed | 151 (60) | 206 (59) | |
Student | 10 (4) | 13 (4) | |
Retired | 16 (6) | 5 (1) | |
Houseperson | 31 (12) | 46 (13) | |
Unemployed job seeker | 10 (4) | 31 (9) | |
Unemployed due to ill-health | 34 (13) | 48 (14) | |
History of depression | |||
Family history | 167 (66) | 210 (60) | 0.14 |
Previous depression | 183 (73) | 252 (72) | 0.96 |
Previous antidepressants | 143 (57) | 182 (52) | 0.28 |
Severity of depressiond | 0.46 | ||
Mild | 24 (10) | 27 (8) | |
Moderate | 132 (52) | 173 (50) | |
Severe | 196 (38) | 149 (43) | |
Antidepressant treatmente | <0.001 | ||
Continued on medication | 173 (69) | 165 (47) | |
Discontinued medication | 79 (31) | 184 (53) |
In addition to those presented here, a further five variables demonstrated no differences between responders and non-responders and are omitted for brevity, namely drug allocation, side-effects 2 weeks after randomisation, improvement in BDI (halving of baseline score) at 6 and 12 weeks, and remission at 6 weeks (BDI <10).
Other ethnicities: Asian/British Asian (n = 3), Black/Black British (n = 3), mixed (n = 1), other (n = 1).
Fisher's exact test.
ICD-10 depression severity, assessed using the CIS-R.
Self-reported adherence to study medication at last completed follow-up.