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. Author manuscript; available in PMC: 2011 Mar 23.
Published in final edited form as: Nat Prod Rep. 2009 Sep 1;26(11):1362–1384. doi: 10.1039/b817069j

Fig. 2.

Fig. 2

Circular representation of the actinomycete chromosomes S. coelicolor A3(2), S. erythraea NRRL2338 and S. tropica CNB-440 oriented to the dnaA gene (top). All genomes are scaled to their relative size. The inner rings show a normalized plot of GC skew, while the center rings show a normalized plot of GC content. The outer circles show the distribution of secondary metabolite gene clusters. Biosynthetic gene clusters associated with thiotemplate-based assembly (PKS, NRPS) are depicted in red, terpene clusters in blue, and loci encoding all other secondary metabolic pathways are marked in black. Clusters whose products have been isolated are labeled accordingly.