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. Author manuscript; available in PMC: 2011 Mar 23.
Published in final edited form as: Nat Prod Rep. 2009 Sep 1;26(11):1362–1384. doi: 10.1039/b817069j

Fig. 5.

Fig. 5

The comparative analysis of nucleotide sequences of S. griseus IFO 13350 (top), S. avermitilis MA-4680 (middle) and S. coelicolor A3(2) (bottom) using the MURASAKI program version 1.40 (weight; 45, length; 90). Predicted core regions (blue lines) account for 6.28 Mb of S. coelicolor A3(2), 6.50 Mb of S. avermitilis and 6.39 Mb of S. griseus and are centered about the replication of origin oriC (black arrow). The subtelomeric regions (bold lines) are less conserved with regard to sequence and ortholog distribution and contain more than half of the gene clusters for secondary metabolism (colored triangles).