Fig. 9.
Gene organization and proposed biosynthesis of a phosphonoformate-like compound in Frankia alni ACN14a. (A) Phosphonate biosynthetic gene cluster in F. alni ACN14a. Genes that are responsible for the production of hydroxyethylphosphonate are depicted in grey (minimal cassette consisting of phosphoenolpyruvate mutase ppm, phosphonopyruvate decarboxylase ppd and phosphonoacetaldehyde dehydrogenase adh). (B) Proposed pathway to a hitherto unknown phosphonate antibiotic.