Table 2.

Predicted C/EBP-CREB motifs in promoters of GH-regulated early response genes

1) c-fos promoter

M -374 T G G C T G C A G C C G G C G A G C T G T T C C C G T C A A T C C C T C C C t c c t T T A C A C A G

H -367 T G G C T G C A G C C C G C G A G C A G T T C C C G T C A A T C C C T C C C c c c - T T A C A C A G

M -324 G A T G T C C A T A T T A G G A C A T C T G C G T C A G C A G G T T T C C A C G G C C G G T C C C

H -318 G A T G T C C A T A T T A G G A C A T C T G C G T C A G C A G G T T T C C A C G G C C T T T C C C

2) Cyr61 promoter

Cyr61-1

M -606 T G C C A C T C C G G G T A T T A A T T T G C A A T A C A C T t c t C T T G G C T A A T A A A C A T

H -752 T G C C A C T G T G G G T A T T A A T T T G C A A T T C A C T g a a C T T T G C T A A T A A A C A T

Cyr61-2

M -89 A G A A T T C T a G A A C G C G C C G A C A G A G C t - A C G T C A C T G C A A C A C G C G G C G C C T

H -109 A G A A T T C T g G A A C G C G C A G A C A G A G C c gA C G T C A C T G C A A C A C G C G G C G C C T

3) Btg2 promoter

M -199 c a c a g c a c g g g a g t c c g g t g c t t G T T C C C A A T A A T G A C G TC A G T G A G C G A T G A C C T C A G C G C C t g G G A G G C G C G G

H -254 c a g c t c a g c c g g g c g c a g G T T C C T A G C A C T G A C G A C A G C G A G C G A T G A C C T C A G C G C C g c c a a g g c t g c g a g g g c g

4) SOCS3 promoter

M -632 C T G T C T A C A G G T A A A T G T C G C G C A T C C C C C T C C T C c a c t t c c t a g g t c c c

H -622 C T G C C C G C A G G T G A C T G T C G C A C G T C T C C A A C C T C c g g c t c c c g g g t c t g

Sequences in GH-induced early response genes that were identified as C/EBP-CREB motifs in promoters (−1500 to +200 bp relative to transcription start site), and that were conserved in mouse (M) and human (H) genes, were obtained using Genomatix software. The conserved sequences are in capital letters, and predicted C/EBP-CREB motifs are underlined. Location of each sequence from transcription start site is indicated on left.