. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Curr Drug Metab. 2010 Oct;11(8):693–714. doi: 10.2174/138920010794233477

Table 1.

Enzymes involved in estrogen biosynthesis, their subcellular location, and consequences of single nucleotide polymorphisms in their genes.

Steroidogenic Enzymes	Subcellular Location	Single Nucleotide Polymorphism	Consequence
Cytochrome P450 P450 scc (CYP11A1:cholesterol side-chain cleavage enzyme)	Mitochondria	TBD	TBD
P450 c17 (17α-hydroxylase;17,20-lyase)	Smooth Endoplasmic Reticulum	rs743572	TBD
P450 arom (CYP19A:aromatase)	Smooth Endoplasmic Reticulum	rs2414096 rs2446405	Diabetes Mellitus Insulin Sensitivity
Oxidoreductases 3β-hydroxysteroid dehydrogenase	Smooth Endoplasmic Reticulum	TBD	TBD
17β-hydroxysteroid dehydrogenase	Smooth Endoplasmic Reticulum	rs2830 rs592389 rs615942	Vasomotor Symptoms

TBD: To Be Determined