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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Curr Drug Metab. 2010 Oct;11(8):693–714. doi: 10.2174/138920010794233477

Table 1.

Enzymes involved in estrogen biosynthesis, their subcellular location, and consequences of single nucleotide polymorphisms in their genes.

Steroidogenic Enzymes Subcellular Location Single Nucleotide Polymorphism Consequence
Cytochrome P450
P450 scc (CYP11A1:cholesterol side-chain cleavage enzyme)		 Mitochondria TBD TBD
P450 c17 (17α-hydroxylase;17,20-lyase) Smooth Endoplasmic Reticulum rs743572 TBD
P450 arom (CYP19A:aromatase) Smooth Endoplasmic Reticulum rs2414096
rs2446405		 Diabetes Mellitus
Insulin Sensitivity
Oxidoreductases
3β-hydroxysteroid dehydrogenase		 Smooth Endoplasmic Reticulum TBD TBD
17β-hydroxysteroid dehydrogenase Smooth Endoplasmic Reticulum rs2830
rs592389
rs615942		 Vasomotor
Symptoms

TBD: To Be Determined

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