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. Author manuscript; available in PMC: 2011 Mar 23.
Published in final edited form as: Annu Rev Neurosci. 2010;33:221–243. doi: 10.1146/annurev-neuro-060909-153215

Table 1.

Cognitive phenotypes of NF1 mouse models

Mouse Model Behavioral phenotypes Parallel human symptoms References
Nf1+/− Impaired in
 Morris water maze (hidden platform Learning deficits in specific domain (visual-spatial) Silva et al. (1997)
Contextual fear conditioning Cui et al. (2008)
Lateralized reaction time task Attention deficits Li et al. (2005)
Pre-pulse inhibition
Normal in
 Open field and visible platform water maze
 Cued fear conditioning
Nf123a−/− Impaired in Learning deficits in specific domain (visual-spatial) Costa et al. (2001)
 Morris water maze (hidden platform
Contextual discrimination Motor deficits
Rota-rod
Normal in
Open field and visible platform water maze
 Social transmission of food preference
Nf1flox/+;SynI-cre Impaired in Learning deficits in specific domain (visual-spatial) Cui et al. (2008)
Nf1flox/+;Dlx5/6-cre  Morris water maze (hidden platform
Normal in
 Visible platform water maze