Table 2. Non-gonadotropin protein profile identified in hMG-HP products.
N | Identified impurities | Accession number | hMG-HP manufacturer A Product 1 | hMG-HP manufacturer A Product 2 |
1 | Plasma serine protease inhibitor (protein C inhibitor) | P05154 | XX | XX |
2 | Apolipoprotein D | P05090 | XX | XX |
3 | Insulin-like growth factor-binding protein 7 | Q16270 | XX | XX |
4 | Leukocyte elastase inhibitor | P30740 | XX | XX |
5 | Alpha-2-antiplasmin | P08697 | XX | X |
6 | Zinc-alpha-2-glycoprotein | P25311 | X | XX |
7 | Serum albumin | P02768 | X | X |
8 | Folate receptor alpha | P15328 | X | X |
9 | Urokinase plasminogen activator surface receptor | Q03405 | X | X |
10 | Afamin | P43652 | X | X |
11 | Kininogen-1 | P01042 | X | X |
12 | Reversion-inducing cysteine-rich protein with Kazal motifs | O95980 | X | X |
13 | Alpha-1-antitrypsin | P01009 | X | X |
14 | Plasminogen | P00747 | X | X |
15 | Beta-2-glycoprotein 1 | P02749 | X | X |
16 | Thrombospondin type-1 domain-containing protein 4 | Q6ZMP0 | X | X |
17 | Protein S100-A7 (Psoriasin) | P31151 | X | X |
18 | Alpha-1-acid glycoprotein 1 | P02763 | X | X |
19 | Complement decay-accelerating factor | P08174 | X | X |
20 | Sialate O-acetylesterase | Q9HAT2 | X | |
21 | Alpha-1-microglobulin (protein AMBP) | P02760 | X | |
22 | Ig kappa chain C region | P01834 | X | |
23 | Ig gamma chain C region | P01857 | X | |
24 | Peptidoglycan recognition protein | O75594 | X | |
25 | Golgi phosphoprotein 2 | Q8NBJ4 | X | |
26 | Delta-like protein 1 | O00548 | X | |
27 | Death-associated protein kinase 1 | P53355 | X | |
28 | CD27 antigen | P26842 | X | |
29 | Serotransferrin | P02787 | X | |
30 | TNF receptor superfamily member 21 | O75509 | X | |
31 | CD59 glycoprotein | P13987 | X | |
32 | Folate receptor gamma | P41439 | X | |
33 | Platelet endothelial aggregation receptor 1 | Q5VY43 | X | |
34 | TNF receptor superfamily member 4 | P43489 | X |
hMG-HP = highly purified urinary human menopausal gonadotropin.