Figure 2.

Evasion of immune responses by individual EBV products. Individual EBV products, including proteins, miRNAs, and EBERs, are shown to evade immune responses in both latent (upper) and lytic (lower) infections. For innate immune evasion, three main strategies are employed: (1) manipulating type I and II IFN Jak-STAT pathway; (2) regulating expression and activity of IRFs, and (3) repressing apoptosis signaling. EBV products are indicated in red fonts. PRD: positive regulatory domain; VRE: virus responsive element; ISRE: IFN-stimulated response element