Table 3.
Odds ratios and 95% confidence intervals for additive genetic model of MTHFR polymorphism by MTR genotypes with risk of hearing impairment analyzed by generalized estimating equations in cumulative data.
| MTR | MTHFR | ||||
|---|---|---|---|---|---|
| CC (T = 0) | CT (T = 1) | TT (T = 2) | p | ||
| N | 1933 | 2475 | 759 | ||
| AA (wild-type homozygotes) | 3370 | 1 | 0.7609 (0.6178-0.9372)/T-allele | 0.0102 | |
| AG (heterozygotes) | 1615 | 1 | 1.1040 (0.7963-1.5305)/T-allele | 0.5528 | |
| GG (mutant homozygotes) | 182 | 1 | 1.3231 (0.6332-2.7649)/T-allele | 0.4565 | |
N = 5167
Parenthetical reference shows 95% confidence interval.
[Moderator variable]
age, sex, smoking status, BMI
histories of occupational noise exposure, heart disease, hypertension, and diabetes