Table 5.
Odds ratios and 95% confidence intervals for additive genetic model of MTHFR polymorphism by MTR genotypes, folate and homocysteine with risk of hearing impairment analyzed by a multiple logistic regression in a subgroup analysis.
| No. | ORs (95% confidence interval) | ||||
|---|---|---|---|---|---|
| MTR | Hearing impairment | No hearing impairment | MTHFR/T-allele | folate | homocysteine |
| AA | 126 | 626 | 0.602 * | 0.946 | 1.066 * |
| (0.421-0.861) | (0.861-1.039) | (1.021-1.113) | |||
| AG | 71 | 281 | 1.379 | 0.941 | 0.953 |
| (0.830-2.292) | (0.816-1.084) | (0.893-1.017) | |||
| GG | 7 | 35 | Data not shown (the validity of the model fit is questionable due to small number). | ||
N = 1146
Asterisk shows statistically significance (p < 0.05). Parenthetical reference shows 95% confidence interval.
[Moderator variable]
age, sex, smoking status, BMI
histories of occupational noise exposure, heart disease, hypertension, and diabetes