Figure 4. Synaptic potentiation induced by forskolin at mossy fiber synapse.

(A) Pooled data showing potentiation of mossy fiber synaptic transmission by bath-applied forskolin (10 µM). There was no significant difference in the magnitude of potentiation between wild-type and mutant mice (p = 0.6905, n = 5 each). The effect of serotonin examined in the same mice was shown in (B) and was larger in mutant mice (p = 0.0159). (B) Significant correlation between serotonin- and forskolin-induced synaptic potentiation in mutant mice (r² = 0.8177, p = 0.00351), but not in wild-type mice (r² = 0.5067, p = 0.1775).