Table 3.

Multivariable analysis of clinical factors associated with discontinuation of warfarin in 4,188 subjects newly starting warfarin

	Hazard Ratio [95% confidence interval]
Age (years)
<65	1.33 [1.03-1.72]
65-74	1.14 [0.88-1.46]
75-84	1.01 [0.79-1.30]
≥ 85	Referent
Female	0.86 [0.76-0.96]
Prior ischemic stroke	0.51 [0.38-0.67]
Diagnosed heart failure	0.71 [0.62-0.81]
Diagnosed hypertension	0.92 [0.82-1.03]
Diabetes mellitus	0.77 [0.65-0.91]
Percent time in therapeutic INR range (per 10% increment)	1.46 [1.42-1.49]
Substituting diagnosed heart failure, hypertension, age, diabetes mellitus, and prior ischemic stroke with CHADS2 score
CHADS2 score
0	2.54 [1.86-3.47]
1	1.98 [1.46-2.70]
2	1.65 [1.20-2.25]
3	1.22 [0.87-1.71]
4-6	Referent
Female	0.86 [0.76-0.96]
Percent time in therapeutic INR range	1.46 [1.42-1.49]

^*Multivariable model included all listed variables in the table