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. Author manuscript; available in PMC: 2011 Jul 7.
Published in final edited form as: Mol Cell. 2011 Jan 7;41(1):82–92. doi: 10.1016/j.molcel.2010.12.017

Figure 7. Hypothetical model for damage-dependent turnover of Rpb1.

Figure 7

The Rpb1 subunit of RNA Pol II holoenzyme (H) irreversibly stalled at sites of DNA lesions is ubiquitinated by the Cul3–RING ligase complex. UbRpb1 can independently recruit proteasome and Ubx5-Cdc48 complexes. UbRpb1 is extracted from its binding partners in an unfolding reaction dependent on Ubx4 or Ubx5-Cdc48 and is threaded into the 26S proteasome.