. Author manuscript; available in PMC: 2012 Apr 1.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Feb 17;21(7):1929–1932. doi: 10.1016/j.bmcl.2011.02.055

Table 1.

Isolated yields of 2,3-substituted quinoxalin-6-amine analogs.

Entry	R¹	R²	R³	R⁴	% Isolated yield
5a	Methyl	-COCH₃	-H	-H	64
5b	2-Furanyl	-COCH₃	-H	-H	84
5c	2-Thienyl	-COCH₃	-H	-H	77
5d	Phenyl	-COCH₃	-H	-H	70
5e	Methyl	-C(=O)-NHPh	-H	-H	83
5f	2-Furanyl	-C(=O)-NHPh	-H	-H	77
5g	2-Thienyl	-C(=O)-NHPh	-H	-H	70
5h	Phenyl	-C(=O)-NHPh	-H	-H	80
5i	Methyl	-H	-H	-SO₂Tol	65
5j	2-Furanyl	-SO₂Tol	-SO₂Tol	-H	66
5k	2-Thienyl	-SO₂Tol	-SO₂Tol	-H	69
5l	Phenyl	-SO₂Tol	-H	-H	65

	R¹	R⁵

6a	2-Furanyl	-C(=S)-NHPh			70
6b	2-Thienyl	-C(=S)-NHPh			74
6c	Phenyl	-C(=S)-NHPh			75
6d	2-Furanyl	-C(=S)-NH-(4-Nitro)-Phenyl			78
6e	2-Thienyl	-C(=S)-NH-(4-Nitro)-Phenyl			80
6f	Phenyl	-C(=S)-NH-(4-Nitro)-Phenyl			80
6g	Methyl	-CO-Pyrrolidine			55
6h	2-Furanyl	-CO-Pyrrolidine			57
6i	Phenyl	-CO-Pyrrolidine			40
6j	Methyl	-C(=O)-NH-(4-Benzyl)-Piperidine			50
6k	2-Furanyl	-C(=O)-NH-(4-Benzyl)-Piperidine			53
6l	Methyl	-CO-Piperdine			54
6m	2-Furanyl	-CO-Morpholine			80

	R¹	R⁶

7a	2-Furanyl	-F			80
7b	2-Furanyl	-Cl			81
7c	2-Furanyl	-Br			76
7d	2-Furanyl	-Phenyl			71