Figure 3.

Development of Monocytes in γc-Deficient Patient and Antigen Presentation

(A) Phenotype of DR⁺ cells is analyzed by flow cytometry analysis of blood from γc-deficient patient (lacking T, B, and NK cells) versus controls. The bar graph represents the percentage (mean ± SD) of CD14^dim monocytes among DR+ cells in three patients and ten controls.

(B) Antigen presentation assay. Monocyte subsets and DCs, from a tetanus toxoid-immunized donor were incubated with autologous T cells and tetanus toxoid. Thymidine incorporation measured during the last 18 hr. IL-2 is measured after 4 days. Data in (B) represent the mean ± SD of triplicates, from experiments representative of three donors.