Fig. 1.
HIV antigen pulsed APC stimulation inhibits IFN-g production in 2B4+ CD8+ T cells. 2B4− and 2B4+ CD8+ T cells were primed either without peptide or with Influenza and HIV-peptide pulsed APCs. IFN-γ released was measured by ELISA after first and second stimulation with APCs, approximately 8 and 16 days respectively. PBMCs from HIV-negative HLA B14 donor (BLCL-2) after 8 days (A) and 16 days of stimulation (B). (*- p<0.05; 2 way ANOVAs detected significant differences between 2B4+ CD8+ T cells stimulated with HIV peptides and FL-8).