. Author manuscript; available in PMC: 2012 Apr 1.

Published in final edited form as: Genet Epidemiol. 2011 Feb 9;35(3):190–200. doi: 10.1002/gepi.20568

Table 2.

Median ORs using different approaches for frequency-matched case-control studies with respect to secondary phenotype, using different prevalence values of primary disease and secondary phenotype, based on 1,000 replicates, each with 1,000 cases and 1,000 frequency-matched controls with respect to secondary phenotype.

		f_D = 10%			f_D = 20%			f_D = 40%			f_D = 60%
OR_t	f_T	$\hat{O R}$	OR_IPW	${\tilde{O R}}_{m}$	$\hat{O R}$	OR_IPW	${\tilde{O R}}_{m}$	$\hat{O R}$	OR_IPW	${\tilde{O R}}_{m}$	$\hat{O R}$	OR_IPW	${\tilde{O R}}_{m}$
1.5	5%	1.43	1.42	1.51	1.38	1.38	1.51	1.35	1.35	1.51	1.37	1.37	1.50
	15%	1.42	1.43	1.50	1.39	1.39	1.51	1.34	1.35	1.51	1.37	1.36	1.50
	40%	1.44	1.45	1.50	1.40	1.39	1.50	1.34	1.34	1.49	1.36	1.36	1.51
	60%	1.46	1.45	1.51	1.41	1.40	1.50	1.36	1.36	1.50	1.35	1.34	1.50
	80%	1.45	1.46	1.50	1.42	1.42	1.50	1.36	1.36	1.50	1.34	1.34	1.49
2.0	5%	1.89	1.90	2.00	1.82	1.84	2.00	1.79	1.79	2.01	1.81	1.81	2.00
	15%	1.90	1.90	2.00	1.83	1.83	2.00	1.79	1.80	2.01	1.81	1.81	2.00
	40%	1.91	1.93	2.00	1.86	1.85	1.99	1.80	1.80	2.01	1.80	1.80	2.00
	60%	1.91	1.93	1.98	1.86	1.88	1.99	1.82	1.81	2.01	1.79	1.78	2.00
	80%	1.94	1.94	2.00	1.91	1.91	2.02	1.81	1.80	1.98	1.79	1.79	2.02
3.0	5%	2.81	2.84	3.00	2.70	2.74	2.97	2.68	2.69	3.00	2.74	2.73	3.02
	15%	2.84	2.85	3.00	2.75	2.76	3.00	2.69	2.69	3.02	2.71	2.72	3.02
	40%	2.85	2.85	2.98	2.77	2.78	2.99	2.68	2.67	3.00	2.68	2.68	2.99
	60%	2.89	2.92	3.02	2.81	2.83	3.02	2.70	2.70	3.01	2.68	2.68	3.03
	80%	2.91	2.93	3.01	2.81	2.80	2.99	2.72	2.71	3.01	2.68	2.68	3.00

OR_t = the true OR of the genetic variant associated with the secondary phenotype