TABLE II.
Baseline Pulmonary Physiology, Exercise Physiology, and Bronchoalveolar Lavage in BeS and CBD Subjects Stratified by Smoking Status
| Never smokers | Ever smokers | |||||
|---|---|---|---|---|---|---|
| BeS (n = 83) | CBD (n = 81) | P-value | BeS (n = 146) | CBD (n = 90) | P-value | |
| Pulmonary function | ||||||
| FVCa | 89.5 (59–121) | 92 (43–129) | 0.46 | 90 (31–126) | 91 (45–129) | 0.87 |
| FEV1a | 94.5 (62–127) | 96.5 (47–126) | 0.65 | 92 (34–137) | 94.5 (56–127) | 0.49 |
| FEV1/FVCa | 107 (71–135) | 108 (64–128) | 0.75 | 105 (67–136) | 106 (77–140) | 0.30 |
| TLCa | 103 (77–169) | 106 (66–139) | 0.34 | 109 (59–137) | 105 (70–154) | 0.03 |
| DLCOa | 96 (69–146) | 94 (44–146) | 0.80 | 90.5 (26–143) | 88 (55–144) | 0.93 |
| Exercise physiology | ||||||
| Maximum workload (W) | 175 (12–300) | 177.5 (90–270) | 0.32 | 160 (20–300) | 166 (60–320) | 0.72 |
| VO2 at maximal exercise (L/min) | 1.92 (.66–3.5) | 2.0 (1.2–3.2) | 0.22 | 1.9 (.61–3.3) | 2.0 (.96–3.1) | 0.54 |
| PaO2 at rest (mm Hg) | 74 (34–88) | 74 (56–89) | 0.99 | 70 (52–94) | 70 (48–83) | 0.94 |
| PaO2 at maximal exercise (mm Hg) | 78.8 (59–97) | 80 (57–99) | 0.69 | 77 (40–83) | 76 (48–93) | 0.58 |
| (A-a)PaO2 at rest (mm Hg) | 6 (0–21) | 7 (0–23) | 0.47 | 10 (0–27) | 12 (0–32) | 0.11 |
| (A-a)PaO2 at max exercise (mm Hg) | 12 (0–32) | 13 (0–36) | 0.45 | 13.6 (0–35) | 17 (0–45) | 0.12 |
| Bronchoalveolar lavage | ||||||
| Peak blood BeLPT (SI) | 3.6 (.6–306.1) | 5.0 (.5–162.5) | 0.05 | 2.3 (.5–174.1) | 4.4 (.3–83.1) | 0.01 |
| Peak lavage BeLPT (SI) | 1.5 (.8–18.5) | 7.6 (.5–362.4) | <0.0001 | 1.5 (0–18.2) | 8.1 (.9–503.6) | <0.0001 |
| Percentage lymphocytes | 9.8 (1.5–48) | 26 (1.9–74) | <0.0001 | 9 (.5–42.5) | 22.9 (1.2–95.7)) | <0.0001 |
Data are medians (ranges) or frequencies (percentages). Kruskal–Wallis rank sum tests were used to compare the continuous variables, while Chi-square tests or Fisher’s exact tests were used to compare the categorical variables.
a
Percent predicted.