TABLE V.
Progression of Illness for CBD Never Smokers: Non-Machinist Versus Machinist
| Average change per year |
Average measure 10 years after first exposure |
Average measure 30 years after first exposure |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-machinist | Machinist | P-valuea | Non-machinist | Machinist | P-valuea | Non-machinist | Machinist | P-valuea | |
| Pulmonary function | |||||||||
| FVC (L) | −0.02 | −0.05 | <0.01 | 4.80 | 4.94 | 4.47 | 3.88 | <0.01 | |
| FEV1 (L) | −0.01 | −0.03 | <0.01 | 3.58 | 3.69 | 3.47 | 3.00 | <0.05 | |
| FEV1/FVC (%) | 0.17 | 0.02 | 74.7 | 75.8 | 78.2 | 76.2 | |||
| TLC (L) | 0.001 | −0.02 | 6.85 | 6.68 | 6.88 | 6.37 | <0.1 | ||
| DLCO (L) | −0.79 | −0.84 | 45.1 | 44.6 | 29.3 | 27.9 | |||
| Exercise physiology | |||||||||
| Max workload (W) | −0.31 | −1.08 | 199.6 | 203.0 | 193.5 | 181.4 | |||
| VO2 at maximal exercise (L/min) | −0.01 | −0.01 | 2.29 | 2.28 | 2.10 | 2.07 | |||
| PaO2 at rest (mm Hg) | −0.26 | −0.63 | <0.05 | 78.5 | 82.2 | 73.2 | 69.5 | ||
| PaO2 at maximal exercise (mm Hg) | −0.63 | −0.71 | 87.7 | 90.1 | 75.1 | 76.0 | |||
| (A-a)PaO2 at rest (mm Hg) | −0.01 | 0.22 | <0.1 | 8.24 | 5.19 | 8.05 | 9.64 | ||
| (A-a) PaO2 at maximal exercise (mm Hg) | 0.20 | 0.29 | 10.1 | 9.9 | 14.1 | 15.7 | |||
| Blood and BAL fluid markers | |||||||||
| Peak blood BeLPT (SI) | −0.39b | −0.48b | 13.6 | 16.4 | 3.7 | 4.2 | |||
| Peak BAL BeLPT (SI) | 0.07b | −0.32b | 6.0 | 13.2 | 7.3 | 5.6 | |||
| BAL lymphocyte (%) | −0.86 | −1.24 | 38.2 | 50.5 | <0.1 | 21.0 | 25.7 | ||
| WBC/CC | −0.69b | −0.75b | 32.3 | 35.2 | 16.4 | 17.8 | |||
Tabled values are average estimates, obtained from mixed model analysis. Results apply to white males aged 52, height of 68 inches, 1970s start of employment, in the nuclear weapons industry.
a
P-value for non-machinist versus machinist comparison.
b
Average slope between 10 and 40 years from first exposure.