Table 1.

A summary of therapeutic strategies in metabolic manipulation

1. Preventing oxygen damage

i) Supplementation of naturally occurring antioxidants

ii) Mitochondria-targeted scavenging compounds

iii) Uncoupling of the mitochondrial respiratory chain

2. Preventing lipid peroxidation

3. Restoring the mitochondrial membrane potential

4. Modulation of mitochondrial calcium homeostasis

5. Transcription regulation