Table 2.
Chromosomal loci showing significant differences in frequency of gain or loss by array comparative genomic hybridization between BRCA1 and BRCA2 related and sporadic breast cancers [185]
| Locus | Frequency | p-value | ||||
|---|---|---|---|---|---|---|
| BRCA1 | BRCA2 | Sporadic | BRCA1 vs sporadic | BRCA2 vs sporadic | BRCA1 vs BRCA2 | |
| Gains | ||||||
| 1cen-p13 | 89 | 68 | 87 | 0.054 | ||
| 3pter-p22 | 33 | 16 | 0 | 0.006 | ||
| 3q13-q27 | 67 | 56 | 13 | 0.000 | 0.073 | |
| 8p12-cent | 11 | 16 | 47 | 0.012 | ||
| 9p | 33 | 16 | 3 | 0.078 | ||
| 9q22-q34 | 0 | 32 | 3 | 0.013 | ||
| 10pter-p12 | 50 | 20 | 7 | 0.000 | ||
| 10p12-q21 | 36 | 4 | 3 | 0.089 | ||
| 13q3 | 25 | 8 | 0 | 0.059 | ||
| 16p | 17 | 24 | 57 | 0.019 | ||
| 18p | 28 | 16 | 3 | 0.025 | ||
| Losses | ||||||
| 5cent-q23 | 72 | 40 | 27 | 0.025 | ||
| 14q1-q2 | 39 | 8 | 10 | 0.048 | ||