Table 1.
RAD51-135C frequency in BRCA1 and BRCA2 mutation carriers
| Disease status |
BRCA1
carriers
|
BRCA2 carriers
|
||
|---|---|---|---|---|
| RAD51-135C frequency | Mean age*, SD | RAD51-135C frequency** | Mean age*, SD | |
| Healthy | 3/49 (6.1%) | 47.8 (13.5) | 2/41 (4.9%) | 45.6 (10.7) |
| Total affected | 12/121 (9.9%) | 44.9 (10.3) | 8/46 (17.4%) | 49.9 (10.9) |
| Unilateral breast cancer | 6/64 (9.4%) | 43.0 (10.6) | 5/28 (17.9%) | 46.0 (9.2) |
| Bilateral breast cancer | 0/14 (0%) | 41.9 (7.8) | 1/5 (20%) | 45.6 (10.4) |
| Breast & ovarian cancer | 3/13 (23%) | 50.4 (7.4) | 1/1 (100%) | 62 |
| Ovarian cancer | 3/30 (10%) | 48.0 (10.6) | 1/12 (8.3%) | 61.2 (7.3) |
*
Mean age was not significantly different between affected and unaffected BRCA1 carriers. In BRCA2 carriers, P = 0.07.
**
In BRCA2 carriers χ2 = 11.1 for RAD51-135C frequency and disease status (4 df), P = 0.03. For RAD51-135C frequency in healthy vs. affected carriers, P = 0.07.