Table 2.
Relative frequency of the common BRCA1 and BRCA2 mutations in Ashkenazi Jewish subjects and families affected with breast/ovarian cancer
| Study subjects | Number | Affected BRCA1 carriers, % | Affected BRCA2 carriers, % | Ref. |
|---|---|---|---|---|
| Unselected living breast cancer cases | 412 | 34 (8.3%) | 15 (3.6%) | 23 |
| Unselected breast cancer cases, pathology slides | 268 | 10 (3.7%) | 8 (3%) | 6 |
| Unselected ovarian cancer cases | 208 | 57 (27%) | 29 (14%) | 24 |
| Selected breast cancer cases | 178 | 16 (9%) | 8 (4.5%) | 25 |
| Breast and breast/ovarian families | 220 | 91 (41%) | 9 (4%) | 26 |
| Families with known BRCA1/BRCA2 mutations | 205 | 141 (69%) | 64 (31%) | This study |
| Breast or ovarian cancer survivors among Jewish volunteers | 302 | 16 (5.3%) | 11 (3.6%) | 5 |