Figure 1.

Hypothesis for apparent diffusion coefficient (ADC) value changes in brain tissue. Schema depicting the standard (A, B) and our working hypothesis (C, D) to explain decreased brain ADC values following silencing of AQP4 expression. Classically, decreased ADC is associated with decreased extracellular space due to cellular swelling (B). The water channel, AQP4, is expressed in astrocyte membranes and can facilitate water movement (C). After silencing APQ4, we hypothesize that lower ADC values are caused by decreased water permeability due to a decreased number of AQP4 channels (D).