Table 2.
Time | PBA | CL | A | BF_SK | MET |
---|---|---|---|---|---|
Inhalation | |||||
5 | −0.744 | −0.088 | −0.055 | 0.017 | 0.212 |
10 | −0.716 | −0.101 | −0.059 | 0.046 | 0.266 |
20 | −0.689 | −0.096 | −0.061 | 0.045 | 0.231 |
28 | −0.679 | −0.108 | −0.067 | 0.055 | 0.236 |
31 | −0.431 | −0.21 | −0.119 | 0.147 | 0.465 |
35 | −0.402 | −0.201 | −0.123 | 0.177 | 0.279 |
40 | −0.395 | −0.165 | −0.154 | 0.17 | 0.123 |
60 | −0.446 | −0.219 | −0.156 | 0.119 | 0.234 |
90 | −0.4 | −0.251 | −0.152 | 0.072 | 0.224 |
120 | −0.335 | −0.264 | −0.161 | 0.088 | −0.024 |
Dermal | |||||
5 | 0.119 | −0.072 | −0.046 | 0.902 | 0.051 |
10 | 0.031 | −0.085 | −0.053 | 0.799 | −0.014 |
20 | −0.123 | −0.097 | −0.06 | 0.627 | −0.171 |
28 | −0.225 | −0.103 | −0.064 | 0.516 | −0.287 |
31 | −0.258 | −0.105 | −0.065 | 0.48 | −0.325 |
35 | −0.319 | −0.11 | −0.069 | 0.4 | −0.392 |
40 | −0.481 | −0.12 | −0.075 | 0.222 | −0.569 |
60 | −1.032 | −0.139 | −0.096 | −0.376 | −1.213 |
90 | −1.319 | −0.19 | −0.126 | −0.745 | −1.55 |
120 | −1.038 | −0.234 | −0.15 | −0.551 | −1.452 |
Abbreviations: PBA, blood:air partition coefficient; CL, liver clearance; A, ratio of kidney/liver clearance; BF_SK, percentage of cardiac output to skin compartment; MET, metabolic equivalent.
Only selected parameters were presented.