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Predicted 3D structure of FRP-C. Bayes empirical Bayes selected sites identified under M8 (Yang 1997; Yang et al. 2005) were identified in Kelleher et al. (2007). Sites that are determinants of protease inhibitor susceptibility are open (reviewed in Srinivasan et al. 2006). Shaded sites comprise the catalytic triad (reviewed in Polgar 2005). Selected sites 124, 244, and 246 also are determinants of inhibitor susceptibility.
