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. 2010 Dec 1;17(7-8):905–914. doi: 10.1089/ten.tea.2010.0275

FIG. 4.

FIG. 4.

Quantification of the number of perfused vessels in fibrin-based CD31-stained constructs in (A) 5 mg/mL fibrin, (B) 10 mg/mL fibrin, (C) 15 mg/mL fibrin as a function of the cellular conditions with HUVECs alone (O), and HUVECs+MSCs (□) gels. For panels (A and B), graphic file with name inl-1.jpg indicates a statistically significant difference (p < 0.05) between the HUVECs+MSCs (□) condition and HUVECs alone (O) condition at day 21. The same data are also represented for (D) HUVECs alone, and (E) HUVECs+MSCs in 5 mg/mL fibrin (O), 10 mg/mL fibrin (•), or 15 mg/mL fibrin (□) at days 3, 7, and 21. For panel (D), graphic file with name inl-1.jpg indicates a statistically significant difference (p < 0.05) between the 5 mg/mL fibrin (O) condition and 10 mg/mL fibrin (•) condition at day 21. For panel (E), graphic file with name inl-1.jpg indicates a statistically significant difference (p < 0.05) between the 5 mg/mL fibrin (O) condition relative to the other fibrin conditions at day 21. Representative histology images of perfused constructs at day 21 in (F) 5 mg/mL fibrin implants containing HUVECs+MSCs and in (G) 5 mg/mL fibrin containing HUVECs alone; asterisks mark extravascular red blood cells. Color images available online at www.liebertonline.com/tea.