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. Author manuscript; available in PMC: 2011 Mar 24.
Published in final edited form as: J Am Chem Soc. 2008 May 7;130(21):6859–6866. doi: 10.1021/ja800888d

Table 2.

Melting Temperatures for DNA Complexes Containing Nonacetylated and Acetylated Hairpin Polyamides Targeted to DNA Sequence 5′-TGGTCA-3′a

DNA sequence = 5′-CGA TGGTCA AGC-3′
Polyamides Tm/°C ΔTm/°C
— 57.2 (±0.2) —
graphic file with name nihms278098t17.jpg (6) 74.1 (±0.3) 16.9
graphic file with name nihms278098t18.jpg (7) 76.1 (±0.2) 18.9
graphic file with name nihms278098t19.jpg (8) 77.5 (±0.3) 20.3
graphic file with name nihms278098t20.jpg (17) 70.0 (±0.1) 12.8
graphic file with name nihms278098t21.jpg (18) 68.9 (±0.2) 11.7
graphic file with name nihms278098t22.jpg (19) 75.0 (±0.1) 17.8
a

All values reported are derived from at least three melting temperature experiments with standard deviations indicated in parentheses. ΔTm values are given as Tm(DNA/polyamide) – Tm(DNA).