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. Author manuscript; available in PMC: 2011 Mar 28.
Published in final edited form as: Sci Signal. 2010 Sep 28;3(141):ra70. doi: 10.1126/scisignal.2001152

Fig. 6.

Fig. 6

Requirements for phosphorylation of Ser1700, Thr1704, and Ser1928 for basal CaV1.2 channel activity. (A and B) Coupling efficiency (nA/pC) and current-voltage relationships for wild-type CaV1.2Δ1800 + DCT channels or channels with alanine substitutions at Ser1700, Thr1704, and Ser1928 individually or simultaneously. *P < 0.05 or **P < 0.01 versus wild-type CaV1.2Δ1800 + DCT channels (ITail, peak tail current; Q, total gating current; Vrev, reversal potential). (C) Coupling efficiency (nA/pC) and current-voltage relationships for CaV1.2Δ1800 + DCT channels with triple-alanine substitution (S1700A, T1704A, and S1928A) or wild-type channels in the presence or absence of 1 μM RO 31-8220. **P < 0.01 versus CaV1.2Δ1800 + DCT channels in control conditions. (D) Coupling efficiency (nA/pC) and current-voltage relationships for CaV1.2FL channels with triple-alanine substitution (S1700A, T1704A, and S1928A) or wild-type channels in the presence or absence of 1 μM RO 31-8220. **P < 0.01 versus wild-type CaV1.2FL channels in control conditions. Significance was determined by ANOVA.