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. 2011 Apr;337(1):218–225. doi: 10.1124/jpet.110.176271

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Fig. 3. — Effects of PAL analogs on extracellular 5-HT in nucleus accumbens of rats undergoing in vivo microdialysis. Rats received intravenous injection of 1 mg/kg of drug at time 0, followed by 3 mg/kg at 60 min. Extracellular 5-HT was determined by HPLC-ECD as described under Materials and Methods; mean basal concentration of 5-HT was 0.19 ± 0.03 pg/5 μl for n = 28 rats. Left, for time course data, dialysate 5-HT values are mean ± S.E.M. expressed as a percentage of three preinjection baseline samples (% basal). Arrows indicate times of drug injection. Right, for mean effect data, 5-HT values are mean ± S.E.M. expressed as the average 5-HT response determined from three postinjection samples after each dose. n = 7 rats/group. *, p < 0.05 compared with all other groups.